Chin. J. Org. Chem. ›› 2013, Vol. 33 ›› Issue (01): 154-158.DOI: 10.6023/cjoc201206013 Previous Articles     Next Articles



王应红, 杨录, 刘志昌   

  1. 乐山师范学院化学学院 乐山 614000
  • 收稿日期:2012-06-12 修回日期:2012-10-08 发布日期:2012-10-12
  • 通讯作者: 刘志昌
  • 基金资助:

    四川省科技厅应用基础(No. 2010JY0148)和四川省乐山市科技局重点(No. 08SZD092)资助项目

Synthesis and Antibacterial Activity of 5-(2-Hydroxyphenyl)-1,3,4- thiadiazol-2-yl-sulfanyl Acetyl Hydrazones

Wang Yinghong, Yang Lu, Liu Zhichang   

  1. Department of Chemistry, Leshan Normal University, Leshan 614000
  • Received:2012-06-12 Revised:2012-10-08 Published:2012-10-12
  • Supported by:

    Project supported by the Application of Basic Project of the Science and Technology Agency of Sichuan Province (No. 2010JY0148) and the Key Projects of the Science and the Technology Bureau of Leshan City in Sichuan Province (No. 08SZD092).

A series of 5-(2-hydroxyphenyl)-1,3,4-thiadiazol-2-yl-sulfanyl acetyl hydrazones were synthesized with 2-mercapto-5-(2-hydroxyphenyl)-1,3,4-thiadiazole as starting material, followed by thioetherification, hydrazide reaction and hydrazone reaction. The structures of these compounds were characterized by 1H NMR, 13C NMR, IR, MS techniques and elemental analysis. The antimicrobial activities of these compounds were also originally studied. The results showed that most of these compounds have potent antibacterial activities. These compounds of aromatic aldehyde-5-(2-hydroxyphen-yl)-1,3,4- thiadiazol-2-yl-sulfanyl acetyl hydrazone (4a4h) showed better antibacterial activities than 2-butenal-5-(2-hydroxyphenyl)-1,3,4-thiadiazol-2-yl-sulfanyl acetyl hydrazone (4i).

Key words: 2-mercapto-5-(2-hydroxyphenyl)-1,3,4-thiadiazole, acyl hydrazones, synthesis, antibacterial activity