Chin. J. Org. Chem. ›› 2013, Vol. 33 ›› Issue (01): 90-100.DOI: 10.6023/cjoc201207003 Previous Articles     Next Articles



乐贵洲a,c, 杨立a, 袁长春a, 杜彪a, 刘波a,b   

  1. a 四川大学化学学院 绿色化学与技术教育部重点实验室 成都 610064;
    b 中国科学院上海有机化学研究所 中国科学院天然产物合成化学重点实验室 上海 200032;
    c 四川农业大学生命科学与理学院 雅安 625014
  • 收稿日期:2012-07-03 修回日期:2012-08-31 发布日期:2012-09-05
  • 通讯作者: 刘波
  • 基金资助:

    国家自然科学基金(Nos. 20872098, 21021001, 21172154);国家重点基础研究发展规划(973计划, No. 2010CB833200).

Progress in Total Syntheses of Lindenane-Type Sesquiterpenoids and Their Dimers

Yue Guizhoua,c, Yang Lia, Yuan Changchuna, Du Biaoa, Liu Boa,b   

  1. a Key Laboratory of Green Chemistry & Technology of Ministry of Education, College of Chemistry, Sichuan University, Chengdu 610064;
    b Key Laboratory of Synthetic Chemistry of Natural Substances, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032;
    c School of Life and Science, Sichuan Agricultural University, Ya'an 625014
  • Received:2012-07-03 Revised:2012-08-31 Published:2012-09-05
  • Supported by:

    Project supported by the National Natural Science Foundation of China (Nos. 20872098, 21021001, 21172154), the National Basic Research Program of China (973 Program, No. 2010CB833200).

Lindenane-type sesquteripenoids and their dimers, mainly isolated from chloranthaceae, are a big family of natural products, which possess novel polycyclic framework embedded with a sterically congested cyclopentane (ring B), an unusual trans-5/6 ring junction, and an angular methyl group. Moreover, many of them exhibited impressing bioactivities, for example remarkable antifungal activity, toxicity-mediated immunosuppression against B cells, and selective inhibition on the delayed rectifier K+current. In this review, the progress in the total syntheses of lindenane-type sesquiterpenoids and their dimmers is summarized.

Key words: lindenane, sesquiterpenoid, dimer, total synthesis