Chin. J. Org. Chem. ›› 2013, Vol. 33 ›› Issue (01): 46-65.DOI: 10.6023/cjoc201207019 Previous Articles     Next Articles



唐初a, 陈玉b, 柏舜b, 杨光忠a   

  1. a 中南民族大学药学院 武汉 430074;
    b 中南民族大学化学与材料科学学院 武汉 430074
  • 收稿日期:2012-07-16 修回日期:2012-09-08 发布日期:2012-09-12
  • 通讯作者: 杨光忠
  • 基金资助:

    国家科技支撑计划(No. 2012BAI27B06)资助项目.

Advances in the Study of Structural Modification and Biological Activities of Oleanolic Acid

Tang Chua, Chen Yub, Bai Shunb, Yang Guangzhonga   

  1. a College of Pharmacy, South Central University for Nationalities, Wuhan 430074;
    b College of Chemistry and Material Sciences, South Central University for Nationalities, Wuhan 430074
  • Received:2012-07-16 Revised:2012-09-08 Published:2012-09-12
  • Supported by:

    Project supported by the National Key Technology R&D Program in the 12th Five Year Plan of China (No. 2012BAI27B06).

Oleanolic acid is a kind of pentacyclic triterpenoid widely found in natural plants and has various biological activities. In this paper, the research advances of the structural modification of oleanolic acid, as well as anti-diabetes, anti-inflammation, anti-cancer activities in recent fifteen years are reviewed, and many derivatives with excellent biological activity are obtained.

Key words: oleanolic acid, anti-diabetes activity, anti-inflammation activity, anti-cancer activity