Chin. J. Org. Chem. ›› 2013, Vol. 33 ›› Issue (01): 106-109.DOI: 10.6023/cjoc201209019 Previous Articles     Next Articles




  1. 北京理工大学材料学院 北京 100081
  • 收稿日期:2012-09-13 修回日期:2012-10-09 发布日期:2012-10-12
  • 通讯作者: 黄木华
  • 基金资助:

    国家自然科学基金(No. 21202008)资助项目.

Synthesis of 8-Pentyl-guanosine by Direct Glycosylation

Huang Muhua   

  1. School of Materials Science and Engineering, Beijing Institute of Technology, Beijing 100081
  • Received:2012-09-13 Revised:2012-10-09 Published:2012-10-12
  • Supported by:

    Project supported by the National Natural Science Foundation of China (No. 21202008).

8-Pentyl-guanosine was prepared by direct glycosylation based on the easy access to 8-pentyl-guanine, which provided a green chemistry approach to 8-C-substituted guanosine. In addition, this paper reported the isolation and characterization of an iminophosphane intermediate, which provide an experimental evidence for the proposed mechanism.

Key words: 8-alkyl-guanine, direct glycosylation, nitrosopyrimdine, iminophosphane, nucleoside