Chin. J. Org. Chem. ›› 2013, Vol. 33 ›› Issue (04): 704-714.DOI: 10.6023/cjoc201301065 Previous Articles     Next Articles



李远明, 马丽娜, 李志平   

  1. 中国人民大学化学系 北京 100872
  • 收稿日期:2013-01-25 修回日期:2013-03-19 发布日期:2013-03-22
  • 通讯作者: 李志平
  • 基金资助:

    国家自然科学基金(Nos. 21072223, 21272267)、中国人民大学科学研究基金(中央高校基本科研业务费专项资金资助)项目成果(No. 10XNL017)资助项目.

Progress in the Transition-Metal Catalyzed Oxidation of Tertiary Amines

Li Yuanming, Ma Lina, Li Zhiping   

  1. Department of Chemistry, Renmin University of China, Beijing 100872
  • Received:2013-01-25 Revised:2013-03-19 Published:2013-03-22
  • Supported by:

    Project supported by the National Natural Science Foundation of China (Nos. 21072223, 21272267), the Fundamental Research Funds for the Central Universities, and the Research Funds of Renmin University of China (No. 10XNL017).

The oxidation of tertiary amines is an improtant process in nature. In chemistry, organic chemists have made great efforts to study on the simulation of enzymatic funtion of oxidation with transition metal catalyst. It provide us new and efficient protocols for the synthesis of nitrogen compounds. The catalytic reactions also enhances our understanding the mechanism of the oxidation of tertiary amins in living system. During this decade, significant progress has been made in the transition metal catalyzed oxidation of tertiary amines. This review is summarized by five types of oxidative transformation of tertiary amines: (1) synthesis of N-oxides of tertiary amines; (2) oxidative Mannich reaction of tertiary amines; (3) oxidative demethylation of tertiary amines; (4) oxidative amidation of tertiary amines; (5) oxidative transformation of the substituents of tertiary amines.

Key words: tertiary amine, oxidation, transition-metal catalysis, demethylation, amide