Chin. J. Org. Chem. ›› 2013, Vol. 33 ›› Issue (06): 1304-1308.DOI: 10.6023/cjoc201303029 Previous Articles     Next Articles



熊娟, 黄亚, 唐宇, 尤梅, 胡金锋   

  1. 复旦大学药学院天然药物化学教研室 上海 201203
  • 收稿日期:2013-03-19 修回日期:2013-04-11 发布日期:2013-04-17
  • 通讯作者: 胡金锋
  • 基金资助:

    国家自然科学基金(Nos.81273401, 81202420)、教育部高等学校博士学科点(博导类)基金(No.20120071110049)和“博士点新教师基金”(No.20120071120049)以及科技部“重大新药创制”重大专项公共资源平台(No.2011ZX09307-002-01)资助项目.

Pentacyclic Triterpenoids from the Roots of Rhodomyrtus tomentosa

Xiong Juan, Huang Ya, Tang Yu, You Mei, Hu Jinfeng   

  1. Department of Natural Products Chemistry, School of Pharmacy, Fudan University, Shanghai 201203
  • Received:2013-03-19 Revised:2013-04-11 Published:2013-04-17
  • Supported by:

    Project supported by the National Natural Science Foundation of China (Nos.81273401, 81202420), the Ph.D.Programs Foundation of Ministry of Education of China (Nos.20120071110049, 20120071120049) and the Grant of Ministry of Science and Technology (MOST, No.2011ZX09307-002-01).

Eight pentacyclic triterpenoids were isolated from the methanol extract of the roots of Rhodomyrtus tomentosa.By application of spectroscopic methods (especially 1D-, 2D-NMR, MS), the structures were established as 23-cis-p-coumaroyl- oxy-2α,3β-dihydroxyolean-12-en-28-oic acid (1), 23-trans-p-coumaroyloxy-2α,3β-dihydroxyolean-12-en-28-oic acid (2), 3β- O-trans-ferulyl-2α,23-dihydroxyolean-12-en-28-oic acid (3), 3β-O-trans-p-coumaroyl-2α,23-dihydroxyolean-12-en-28-oic acid (4), 3β-O-cis-p-coumaroyl-2α,23-dihydroxyolean-12-en-28-oic acid (5), maslinic acid (6), arjunolic acid (7), and 2α,3β-dihydroxytaraxer-20-en-28-oic acid (8).Among them, compounds 1 and 3 were new oleanane-type triterpenoids, while compounds 2, 46 and 8 were isolated from this plant for the first time.This is the first report on the chemical constituents from the roots of R.tomentosa.

Key words: Rhodomyrtus tomentosa, myrtaceae, chemical constituents, pentacyclic triterpenoids