Chin. J. Org. Chem. ›› 2014, Vol. 34 ›› Issue (8): 1509-1522.DOI: 10.6023/cjoc201402029 Previous Articles     Next Articles



侯学会a, 马志伟a,b, 王建玲a, 刘宏民c   

  1. a 河南牧业经济学院质检系 郑州 450011;
    b 郑州大学化学与分子工程学院 郑州 450001;
    c 郑州大学药学院 郑州 450001
  • 收稿日期:2014-02-24 修回日期:2014-03-12 发布日期:2014-04-28
  • 通讯作者: 侯学会,刘宏民;
  • 基金资助:

Rencent Advances in Asymmetric Michael Addition Catalyzed by Chiral Bifunctional Thioureas

Hou Xuehuia, Ma Zhiweia,b, Wang Jianlinga, Liu Hongminc   

  1. a Department of Quality Detection and Management, Henan University of Animal Husbandry and Economy, Zhengzhou 450011;
    b College of Chemistry and Molecular Engineering, Zhengzhou University, Zhengzhou 450001;
    c School of Pharmaceutical Science, Zhengzhou University, Zhengzhou 450001
  • Received:2014-02-24 Revised:2014-03-12 Published:2014-04-28
  • Supported by:
    Project supported by the Science and Technology Research Projects of Education Department of Henan Province (Nos. 14A150052, 12A150026), the Scientific Research Plan of Zhenzhou City (No. 121PPTGG509-2).

Asymmetric organocatalysis has been a frontier in the field of asymmetric catalysis. The comparable advantages, including mild reaction conditions, environment benign, and so on, render the organocatalytic reaction to possess some features of green chemistry. Chiral amino-thiourea organocatalyst, especially chiral bifunctional thiourea, has been shown excellent catalytic performance in a variety of asymmetric reactions. This review provides an overview of applications of chiral bifunctional thiourea in asymmetry Michael addition reaction, and the prospect and development are depicted finally.

Key words: organocatalysis, bifunctional, chiral thiourea, Michael addition