Chin. J. Org. Chem. ›› 2014, Vol. 34 ›› Issue (12): 2487-2492.DOI: 10.6023/cjoc201406010 Previous Articles     Next Articles



严楠a,b, 夏剑辉b, 熊云奎b, 熊斌b, 林春花a,b, 廖维林a,b   

  1. a. 国家单糖化学合成工程技术研究中心 南昌 330027;
    b. 江西师范大学化工研发中心 南昌 330027
  • 收稿日期:2014-06-18 修回日期:2014-07-09 发布日期:2014-08-29
  • 通讯作者: 林春花
  • 基金资助:


One-Pot Three-Component Synthesis of New β-Indole Derivatives in Gluconic Acid Aqueous Solution

Yan Nana,b, Xia Jianhuib, Xiong Yunkuib, Xiong Binb, Lin Chunhuaa,b, Liao Weilina,b   

  1. a. National Monosaccharide Chemical Synthesis Engineering Research Center, Nanchang 330027;
    b. Chemical Research and Development Center, Jiangxi Normal University, Nanchang 330027
  • Received:2014-06-18 Revised:2014-07-09 Published:2014-08-29
  • Supported by:

    Project supported by the National Science and Technology Support Program of China (No. 2009BAI75B02), the Innovation Fund Designated for Graduate Students of Jiangxi Province (No. YC2014), and the Outstanding Doctoral Dissertation Cultivation Program of Jiangxi Normal University.

One-pot three-component reactions of aldehydes with indole and 2,2-pentamethylene-1,3-dioxane-4,6-dione afforded thirteen kinds of 5-[(indol-3-yl)-methyl]-2,2-pentamethylene-1,3-dioxane-4,6-dione derivatives (β-indole derivatives) in the presence of gluconic acid aqueous solution in 66.4%~98.5% yields. The advantages of this protocol were mild reaction conditions, wide substrate scope, high yields and benign to environment, which afforded an effective method to synthesize β-indole derivatives.

Key words: 2,2-pentamethylene-1,3-dioxane-4,6-dione, gluconic acid aqueous solution, three-component reactions, β-indole derivatives