Chin. J. Org. Chem. ›› 2014, Vol. 34 ›› Issue (11): 2249-2254.DOI: 10.6023/cjoc201408025 Previous Articles     Next Articles


张艳, 罗莎, 冯柏年   

  1. 江南大学药学院 无锡 214122
  • 收稿日期:2014-08-21 修回日期:2014-09-28 发布日期:2014-10-09
  • 通讯作者: 冯柏年,
  • 基金资助:


Iron-Catalyzed Oxidative Phosphonation of α-sp3-C—H Bonds of N-Aryl Tetrahydroisoquinolines with Air as Oxidant

Zhang Yan, Luo Sha, Feng Bainian   

  1. School of Pharmaceutical Science, Jiangnan University, Wuxi 214122
  • Received:2014-08-21 Revised:2014-09-28 Published:2014-10-09
  • Supported by:

    Project supported by the National Natural Science Foundation of China (No.21302067) and the National Natural Science Foundation of Jiangsu Province (No.BK20130120).

An efficient cross-dehydrogenative-coupling (CDC) between sp3-C—H bond adjacent to a nitrogen atom of tertiary amine and H—P bonds of dialkyl phosphites and diaryl phosphate was developed using FeCl3 as catalyst and air as oxidant under mild reaction conditions. The safe, convenient, environmental and efficiently benign to synthesize a series of biologically important α-aminophosphonates.

Key words: sp3-C—H activation, cross-dehydrogenative coupling, oxidative phosphonation, iron catalyst