Chin. J. Org. Chem. ›› 2015, Vol. 35 ›› Issue (5): 1009-1021.DOI: 10.6023/cjoc201409038 Previous Articles     Next Articles



刘颖杰a, 丁泽洋c, 谭冲a, 袁洪亮b, 季宇彬a,b   

  1. a 哈尔滨商业大学商业工程研究院 哈尔滨 150076;
    b 哈尔滨商业大学生命科学与环境科学研究中心 哈尔滨 150076;
    c 吉林大学化学学院 长春 130000
  • 收稿日期:2014-09-24 修回日期:2014-10-29 发布日期:2014-12-10
  • 通讯作者: 季宇彬
  • 基金资助:


Progresses in the Total Synthesis and Structure Modification Studies of Lycorine

Liu Yingjiea, Ding Zeyangc, Tan Chonga, Yuan Hongliangb, Ji Yubina,b   

  1. a Business Engineering Research Institute, Harbin University of Commerce, Harbin 150076;
    b Research Center on Life Science and Enviromental Science, Harbin University of Commerce, Harbin 150076;
    c College of Chemistry, Jilin University, Changchun 130000
  • Received:2014-09-24 Revised:2014-10-29 Published:2014-12-10
  • Supported by:

    Project supported by the Harbin University of Commerce Doctoral Research Project (No.14LG12) and the Natural Science Fund for Young Teachers of Harbin University of Commerce (No.HCUL2013019).

Lycorine is a very important class of isoquinoline alkaloids of the amaryllidaceae alkaloids. In recent years, pharmaceutical and organic chemists discovered that lycorine and their derivatives have anti-tumor, anti-inflammatory, inhibiting acetylcholinesterase, anti-malarial, cardiovascular protection and other effects. Because of its complex and unique molecular structure and extensive pharmaceutical activities, lycorine has attracted considerable research effort. The recent progresses in the synthesis and structural modification of lycorine are summarized in this review.

Key words: lycorine, total synthesis, derivatives, structure modification