Chin. J. Org. Chem. ›› 2015, Vol. 35 ›› Issue (5): 997-1008.DOI: 10.6023/cjoc201409048 Previous Articles     Next Articles



冯俊娜a,b, 高芳a, 彭绍辉b, 陈华a, 李小六a   

  1. a 河北大学化学与环境科学学院 保定 071002;
    b 中国地质大学长城学院 保定 071000
  • 收稿日期:2014-09-30 修回日期:2014-12-06 发布日期:2014-12-18
  • 通讯作者: 陈华, 李小六;
  • 基金资助:


Research Advances of KRN7000 Analogues and Their Immune Activities

Feng Junnaa,b, Gao Fanga, Peng Shaohuib, Chen Hua, Li Xiaoliua   

  1. a College of Chemistry and Environmental Science, Hebei University, Baoding 071002;
    b China University of Geosciences Great Wall College, Baoding 071000
  • Received:2014-09-30 Revised:2014-12-06 Published:2014-12-18
  • Supported by:

    Project supported by the National Natural Science Foundation of China (Nos.20972039, 21372060), the Research Fund for the Doctoral Program of Higher Education of China (No.20121301110004), the Medicinal Joint Funds of the Natural Science Foundation of Hebei and Shijiazhuang Pharmaceutical Group Foundation (No.B2011201169), and the Natural Science Foundations of Education Department of Hebei Province (No.ZH2011110).

KRN7000 has widely biological activities, such as anti-tumor, anti-tuberculosis, anti-fungal, anti-virus, anti-inflammation, and against auto-immune diseases. As the potential immunomodulator, KRN7000 can effectively activate the natural killer T cells (NKT cells) and induce the secretion of IFN-γ and IL-4 cytokines. However, IFN-γ inhibited the activity of T helper 2 cells (TH2) and IL-4 inhibited the activity of T helper 1 cells (TH1), which mediated humoral as well as celluar immune reactions, respectively. The concomitant of functions of TH1 and TH2 limits the therapeutic potential of KRN7000 against immune diseases. Therefore, developing new analogues of KRN7000 to find new immnostimulating drugs has drawn many attentions in the world. This review presents the recent progress in the study on the structure and immune activity of the synthesized KRN7000 derivatives.

Key words: KRN7000, immunomodulator, TH1/TH2