Chin. J. Org. Chem. ›› 2015, Vol. 35 ›› Issue (5): 1146-1151.DOI: 10.6023/cjoc201410024 Previous Articles     Next Articles


天然产物Longistylin A, Longistylin C和Cajanotone的全合成

陈文章a, 王聪a, 樊玲玲a, 王建塔a, 岳炜洲b, 汤磊a   

  1. a 贵阳医学院药学院 贵阳 550004;
    b 中国药科大学药学院 南京 210009
  • 收稿日期:2014-10-17 修回日期:2014-12-05 发布日期:2015-01-09
  • 通讯作者: 汤磊
  • 基金资助:


Total Synthesis of Longistylin A, Longistylin C and Cajanotone

Chen Wenzhanga, Wang Conga, Fan Linglinga, Wang Jiantaa, Yue Weizhoub, Tang Leia   

  1. a College of Pharmacy, Guiyang Medical University, Guiyang 550004;
    b College of Pharmacy, China Pharmaceutical University, Nanjing 210009
  • Received:2014-10-17 Revised:2014-12-05 Published:2015-01-09
  • Supported by:

    Project supported by the Program for New Century Excellent Talents in University (No.NCET-12-0656), the Innovation Ability Promoting Program in University of Guizhou Province (No.2013-04), the Natural Science Fundation for Youth in Universities of Guizhou Province (No.2014-300).

Natural products longistylin A, longistylin C and cajanotone belong to stilbenes family and exhibit varieties of bioactivities. Using Horner-Wadsworth-Emmons (HWE) and 1,3-sigma rearrangement reactions as key steps, longistylin A and longistylin C have been successfully synthesized in six steps from 3,5-dimethoxy benzoic acid. Besides, using Barbier and 1,3-sigma rearrangement reactions as key steps, cajanotone has been first prepared in eight steps from 3,5-dihydroxy benzoic acid.

Key words: longistylin A, longistylin C, cajanotone, total synthesis