Chin. J. Org. Chem. ›› 2015, Vol. 35 ›› Issue (6): 1238-1249.DOI: 10.6023/cjoc201410043 Previous Articles     Next Articles



张霞忠a, 邹润英a, 邓家英a, 周文俊a, 王进贤b   

  1. a 内江师范学院化学化工学院 内江 641112;
    b 西北师范大学化学化工学院 兰州 730070
  • 收稿日期:2014-10-30 修回日期:2014-12-15 发布日期:2015-01-15
  • 通讯作者: 周文俊,
  • 基金资助:

    国家自然科学基金(No. 20572086)、四川省教育厅(Nos. 12ZB074, 13ZB0002)和内江师范学院博士科研启动费(No. 2012B05)资助项目.

Recent Progress of Glycerol as Green Solvents in Organic Synthesis

Zhang Xiazhonga, Zou Runyinga, Deng Jiayinga, Zhou Wenjuna, Wang Jinxianb   

  1. a College of Chemistry and Chemical Engineering, Neijiang Normal University, Neijiang 641112;
    b College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou 730070
  • Received:2014-10-30 Revised:2014-12-15 Published:2015-01-15
  • Supported by:

    Project supported by the National Natural Science Foundation of China (No. 20572086), the Sichuan Province Education Office (Nos. 12ZB074, 13ZB0002), and the Startup Foundation of Ph. D. Scientific Research of Neijiang Normal University.

Traditionally, organic synthesis is carried out in solvents, which not only facilitate the intimate contact of reactants and catalysts but also determines the choice of work up procedures and disposal strategies. Glycerol (1,2,3-propanetriol or glycerin) is easily available as the main by-product of the biodiesel industry. The increased production in the synthesis of biofuel, i.e., biodiesel, has led to a growth in the supply of glycerol, which is a non-toxic and recyclable liquid that is highly inert and stable, and compatible with many other non-irritating and non-toxic chemicals. According to the twelve principles of green chemistry, the features of glycerol are to meet the criteria for green solvents. Recently, glycerol has attracted attention as it is a versatile, cheap, and renewable feedstock and has been proven to be an environmentally friendly reaction media for the synthetic organic chemistry. In many reactions, glycerol as green solvent can improve the yield of the reaction or change the selectivity of the reaction. In order to provide some inspiration of better organic synthetic method design for glycerol, the use of glycerol as a green solvent in organic synthesis is reviewed, such as addition reactions, reduction reactions, coupling reactions, multi-component reactions, and so on.

Key words: biodiesel, glycerol, green solvent, organic synthesis