Chin. J. Org. Chem. ›› 2015, Vol. 35 ›› Issue (6): 1216-1228.DOI: 10.6023/cjoc201411009 Previous Articles     Next Articles

Reviews

铂催化α-酮酸酯不对称氢化反应的研究进展

杨文, 潘雪静, 杨定乔   

  1. 教育部环境理论化学重点实验室 华南师范大学化学与环境学院 广州 510006
  • 收稿日期:2014-11-07 修回日期:2015-01-21 出版日期:2015-06-25 发布日期:2015-02-10
  • 通讯作者: 杨定乔 E-mail:yangdq@scnu.edu.cn
  • 基金资助:

    国家自然科学基金(Nos. 21172081, 21372090)、广东省自然科学基金重点(No. S2013020013091)和广州市科技计划(No. 156300018)资助项目.

Progress in Platinum-Catalyzed Asymmetric Hydrogenation of α-Keto Esters

Yang Wen, Pan Xuejing, Yang Dingqiao   

  1. Key Laboratory of Theoretical Chemistry of Environment, Ministry of Education, School of Chemistry and Environment, South China Normal University, Guangzhou 510006
  • Received:2014-11-07 Revised:2015-01-21 Online:2015-06-25 Published:2015-02-10
  • Supported by:

    Project supported by the National Natural Science Foundation of China (Nos. 21172081, 21372090), the Natural Science Foundation of Guangdong Province (No. S2013020013091) and the City of Guangzhou Science and Technology Plan Projects (No. 156300018).

Platinum-catalyzed enantioselective hydrogenation of α-keto esters is one of the most effective methods for the synthesis of chiral α-hydroxy esters. The recent progress in platinum-catalyzed heterogeneous asymmetric hydrogenation of α-keto esters is reviewed. It was paid great attention to the influences of modified platinum catalyst, supported platinum catalyst, nanoparticle platinum catalysts, and platinum colloids on the asymmetric hydrogenation. What’s more, the possible mechanisms are also discussed in this review.

Key words: platinum catalyst, α-keto esters, asymmetric hydrogenation, cinchona alkaloids