Chin. J. Org. Chem. ›› 2015, Vol. 35 ›› Issue (3): 688-697.DOI: 10.6023/cjoc201412023 Previous Articles     Next Articles



王亮a,b, 瞿星a, 李站a, 彭望明a   

  1. a 江汉大学光电化学材料省部共建教育部重点实验室 武汉 430056;
    b 江汉大学化学与环境工程学院 武汉 430056
  • 收稿日期:2014-12-14 修回日期:2014-01-04 发布日期:2015-01-09
  • 通讯作者: 王亮, 彭望明
  • 基金资助:

    国家自然科学基金(No. 21302064)资助项目.

Rhodium(III)-Catalyzed C—H Activation/Cylization of Indole-2-amides Derivatives and Terminal Alkynes

Wang Lianga,b, Qu Xinga, Li Zhana, Peng Wangminga   

  1. a Key Laboratory of Optoelectronic Chemical Materials and Devices of Ministry of Education, Jianghan University, Wuhan 430056;
    b School of Chemical and Enviromental Engineering, Jianghan University, Wuhan 430056
  • Received:2014-12-14 Revised:2014-01-04 Published:2015-01-09
  • Supported by:

    Project supported by the National Natural Science Foundation of China (No. 21302064)

A simple and efficient Rh-catalyzed the C—H activation/cyclization reaction of indole-2-amides and alkynes was developed. A series of novel pyrido[3,4-b]indol-1-ones can be efficiently obtained with high to excellent yields using the internal oxidant at room temperature. The transformations have a wide range of substrates with various functional groups. Intermolecular competition experiment was conducted, and a plausible mechanism was proposed. The structures of all conpound were confirmed by 1H NMR, 13C NMR and HRMS.

Key words: rhodium catalyst, oxidative directing group, C—H activation, polycyclic indoles