Chin. J. Org. Chem. ›› 2015, Vol. 35 ›› Issue (7): 1570-1575.DOI: 10.6023/cjoc201501012 Previous Articles     Next Articles



葛恬, 宋洁, 姚志刚, 徐凡   

  1. 苏州大学材料与化学化工学部 苏州 215123
  • 收稿日期:2015-01-13 修回日期:2015-02-17 发布日期:2015-03-03
  • 通讯作者: 徐凡
  • 基金资助:

    国家自然科学基金(Nos. 21272168, 20872106)资助项目.

Efficient Synthesis of Arylidene Heterobicyclic Pyrimidinone via Ferric Chloride Catalyzed Biginelli-Type Reaction

Ge Tian, Song Jie, Yao Zhigang, Xu Fan   

  1. College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123
  • Received:2015-01-13 Revised:2015-02-17 Published:2015-03-03
  • Supported by:

    Project supported by the National Natural Science Foundation of China (Nos. 21272168, 20872106).

Pyrimidinone and its functionalized derivatives are known to possess a broad-spectrum of biological activities. This paper described an efficient method for the synthesis of pyrimidinones via ferric chloride catalyzed Biginelli-type condensation of aromatic aldehyde, cyclopentanone, and urea or thiourea. The reactions produce a series of arylidene heterobicyclic pyrimidinones in moderate to excellent yields under solvent-free conditions.

Key words: ferric chloride, catalysis, Biginelli reaction, arylidene heterobicyclic pyrimidinone