Chin. J. Org. Chem. ›› 2015, Vol. 35 ›› Issue (9): 1917-1922.DOI: 10.6023/cjoc201502010 Previous Articles     Next Articles



龚久涵, 朱正, 卢林, 郭生梅, 蔡琥   

  1. 南昌大学化学学院 南昌 330031
  • 收稿日期:2015-02-07 修回日期:2015-05-12 发布日期:2015-05-26
  • 通讯作者: 郭生梅, 蔡琥;
  • 基金资助:

    科技部973计划(No. 2012CBA01204)和国家自然科学基金(No. 21302084)资助项目.

Copper-Catalyzed Oxidative Amidation of Aryl Ketone and ItsDerivatives to Form α-Keto Amides

Gong Jiuhan, Zhu Zheng, Lu Lin, Guo Shengmei, Cai Hu   

  1. College of chemistry, Nanchang University, Nanchang 330031
  • Received:2015-02-07 Revised:2015-05-12 Published:2015-05-26
  • Supported by:

    Project supported by the National Key Basic Research Program of Ministry of Science and Technology of China (No. 2012CBA01204) and the National Natural Science Foundation of China (No. 21302084).

The oxidative amidation between aryl ketone and amine to form keto amide in water was studied. A variety of amides co-catalyzed by copper and iodine were efficiently synthesized using TBHP as an oxidant under room temperature. On the other hand, a copper-catalyzed C—C bond cleavage of β-keto ester and its derivatives to prepare α-keto amides under O2 atmosphere was also studied.

Key words: H2O, O2, aryl ketone, β-keto esters, α-keto amides