Chin. J. Org. Chem. ›› 2015, Vol. 35 ›› Issue (9): 1910-1916.DOI: 10.6023/cjoc201505012 Previous Articles     Next Articles



徐辉, 桂奇飞, 谌志华, 曲浩然, 虞心红   

  1. 华东理工大学药学院 上海 200237
  • 收稿日期:2015-05-06 修回日期:2015-05-21 发布日期:2015-05-29
  • 通讯作者: 虞心红
  • 基金资助:

    国家自然科学基金(Nos. 21476078, 20972051)资助项目.

Basic Ionic Liquid Mediated One-Pot Synthesis of 4-Aminobenzylidene-Scaffold Derivatives

Xu Hui, Gui Qifei, Chen Zhihua, Qu Haoran, Yu Xinhong   

  1. School of Pharmacy, East China University of Science and Technology, Shanghai 200237
  • Received:2015-05-06 Revised:2015-05-21 Published:2015-05-29
  • Supported by:

    Project supported by the National Natural Science Foundation of China (Nos. 21476078, 20972051).

4-Aminobenzylidene derivatives are very important synthetic intermediates. A fast and green protocol for the one-pot multi-component reaction of 4-halobenzaldehyde, active methylene compounds and secondary amines was developed using a basic ionic liquid, 1-methyl-3-butylimidazolium hydroxide, [bmIm]OH, as catalyst, reagent and reaction medium. All the corresponding 4-aminobenzylidene-scaffold derivatives were obtained in good to excellent yields. The [bmIm]OH could be reused. Moreover, the structures of all the products were confirmed by 1H NMR, 13C NMR and MS techniques.

Key words: ionic liquid, multi-component reaction, 4-aminobenzylidene