Chin. J. Org. Chem. ›› 2015, Vol. 35 ›› Issue (11): 2291-2300.DOI: 10.6023/cjoc201505035 Previous Articles     Next Articles



朱辉, 叶长青, 陈知远   

  1. 江西师范大学化学化工学院 功能有机小分子教育部重点实验室 南昌 330022
  • 收稿日期:2015-05-25 修回日期:2015-06-23 发布日期:2015-07-08
  • 通讯作者: 陈知远
  • 基金资助:

    国家自然科学基金(Nos. 21202065, 21462022)和江西省自然科学基金(No. 20142BAB213004)资助项目.

Recent Advances in the Norbornene Mediated Palladium-Catalyzed Domino-Type Catellani Reaction

Zhu Hui, Ye Changqing, Chen Zhiyuan   

  1. Key Laboratory of Functional Small Organic Molecules, Ministry of Education, College of Chemistry & Chemical Engineering, Jiangxi Normal University, Nanchang 330022
  • Received:2015-05-25 Revised:2015-06-23 Published:2015-07-08
  • Supported by:

    Project supported by the National Natural Science Foundation of China (Nos. 21202065, 21462022) and the Natural Science Foundation of Jiangxi Province (No. 20142BAB213004).

Catellani reaction is a kind of domino reaction that can achieve direct functionalization of the unactivated remote aromatic C—H bond, based on the use of a palladium catalyst and norbornene. Through the selective activation of the C—H bond which located at the ortho position of C—X, and a subsequent direct cross coupling reaction in the ipso position of aryl halide, the reaction employing aryl halide as a starting material opens a way for the selective formation of many new chemical bonds, as well as multi-substituted aromatic or aza-heterocyclic derivatives in a single reaction vessel. The recent advancements that introducing different strategies to terminate the typical Catellani reaction are mainly summarized.

Key words: palladium catalyst, norbornene, C—H bond activation, Domino reaction