Chin. J. Org. Chem. ›› 2015, Vol. 35 ›› Issue (12): 2559-2567.DOI: 10.6023/cjoc201507005 Previous Articles     Next Articles



展震, 张国尧, 程旭, 吕光辉, 郑阳, 海俐, 吴勇   

  1. 四川大学华西药学院 成都 610041
  • 收稿日期:2015-07-04 修回日期:2015-08-22 发布日期:2015-08-26
  • 通讯作者: 海俐, 吴勇;
  • 基金资助:

    国家自然科学基金(Nos. 81373259, 81573286)资助项目.

CuCl2-Promoted Friedel-Crafts Hydroxyalkylations of Indoles

Zhan Zhen, Zhang Guoyao, Cheng Xu, Lü Guanghui, Zheng Yang, Hai Li, Wu Yong   

  1. West China School of Pharmacy, Sichuan University, Chengdu 610041
  • Received:2015-07-04 Revised:2015-08-22 Published:2015-08-26
  • Supported by:

    Project supported by the National Natural Science Foundation of China (Nos. 81373259, 81573286).

An Friedel-Crafts hydroxyalkylations reaction was explored for the synthesis of indolyl α-acyloins by treating arylglyoxals, indoles and copper chloride at room temperature in 1,4-dioxane. The method is highly efficient, environmental, low cost and concise manipulation.

Key words: Lewis acid, Friedel-Crafts hydroxyalkylations, arylglyoxals, indoles