Chin. J. Org. Chem. ›› 2015, Vol. 35 ›› Issue (12): 2617-2623.DOI: 10.6023/cjoc201508018 Previous Articles     Next Articles



戴红a,b, 黄菊华a, 金智超a, 成晓燕a, 黄凯薇a, 凌勇c, 汪清民b, 石玉军a   

  1. a 南通大学化学化工学院 南通 226019;
    b 南开大学元素有机化学国家重点实验室 天津 300071;
    c 南通大学药学院 南通 226001
  • 收稿日期:2015-08-18 修回日期:2015-09-11 发布日期:2015-09-17
  • 通讯作者: 凌勇, 石玉军;
  • 基金资助:

    国家自然科学基金(Nos. 21202089, 21372135)、元素有机化学国家重点实验室开放课题(No. 201412)、江苏省大学生创新训练计划和南通市科技计划(Nos. AS2013004, AS2014011)资助项目.

Synthesis and Bioactivities of Novel Pyrazole Oximes Containing Substituted Thiadiazole Moiety

Dai Honga,b, Huang Juhuaa, Jin Zhichaoa, Cheng Xiaoyana, Huang Kaiweia, Ling Yongc, Wang Qingminb, Shi Yujuna   

  1. a College of Chemistry and Chemical Engineering, Nantong University, Nantong 226019;
    b State Key Laboratory of Elemento-organic Chemistry, Nankai University, Tianjin 300071;
    c School of Pharmacy, Nantong University, Nantong 226001
  • Received:2015-08-18 Revised:2015-09-11 Published:2015-09-17
  • Supported by:

    Project supported by the National Natural Science Foundation of China (Nos. 21202089, 21372135), the Open Project Fund of State Key Laboratory of Elemento-organic Chemistry (No. 201412), the Science and Technology Innovation Foundation for the College Students of Jiangsu Province and the Science and Technology Project Fund of Nantong City (Nos. AS2013004, AS2014011).

In order to find novel potent pesticide from pyrazole oxime derivatives, a series of new pyrazole oximes carrying substituted thiadiazole moiety were prepared by the introduction of the key thiadiazole backbone into the molecules of pyrazole oximes. The structures of the title compounds were characterized by 1H NMR, 13C NMR and elemental analysis. Preliminary bioassay data displayed that some of the title compounds showed good insecticidal activities against Aphis craccivora and Nilaparvata lugens. In addition, some target compounds also exhibited certain larvicidal activity against Oriental armyworm.

Key words: substituted thiadiazole, pyrazole oxime, synthesis, biological activity