Chin. J. Org. Chem. ›› 2016, Vol. 36 ›› Issue (2): 425-431.DOI: 10.6023/cjoc201508025 Previous Articles     Next Articles



周鹏, 邱会华, 施继成   

  1. 广东石油化工学院化学工程学院 茂名 525000
  • 收稿日期:2015-08-25 修回日期:2015-10-12 发布日期:2015-10-23
  • 通讯作者: 周鹏
  • 基金资助:

    国家自然科学基金(No. 21272037)和广东省自然科学基金(No. S2013040014944)资助项目.

Palladium Catalyzed Cascade Cyclization of ortho-Alkenyl Bromobenzenes and Internal Alkynes for Multisubstituted Indenes

Zhou Peng, Qiu Huihua, Shi Jicheng   

  1. School of Chemical Engineering, Guangdong University of Petrochemical Technology, Maoming 525000
  • Received:2015-08-25 Revised:2015-10-12 Published:2015-10-23
  • Supported by:

    Project supported by the National Natural Science Foundation of China (No. 21272037) and the Natural Science Foundation of Guangdong Province (No. S2013040014944).

This paper developed a new method for the construction of polysubstituted indenes. And a number of multisubstituted indenes have been synthesized from functional o-alkenyl bromobenzenes and alkynes in good yields through palladium-catalyzed annulations in N,N-dimethylformamide (DMF) taking Na2CO3 as base. The methodology tolerates a variety of functional groups with simple reaction conditions and the catalyst can be reused.

Key words: Pd-catalyzed, alkyne, o-alkenyl bromobenzene, indene, cascade reaction