Chin. J. Org. Chem. ›› 2015, Vol. 35 ›› Issue (12): 2529-2536.DOI: 10.6023/cjoc201509032 Previous Articles     Next Articles



钱文昊a,b, 苏俭生a, 龚雪a, 叶茂b, 徐培成b   

  1. a 上海牙组织修复与再生工程技术研究中心 同济大学口腔医学院口腔修复学教研室 上海 200072;
    b 上海市徐汇区牙病防治所 上海 200032
  • 收稿日期:2015-09-25 修回日期:2015-10-09 发布日期:2015-10-13
  • 通讯作者: 苏俭生, 徐培成;
  • 基金资助:

    国家自然科学基金(Nos. 81371949, 81572114)和上海市生物医药科技重点(No. 13411951200)资助项目.

Studies on Loading Doxorubicin and Coumarin by Medical Biocompatible Graft Copolymer

Qian Wenhaoa,b, Su Jianshenga, Gong Xuea, Ye Maob, Xu Peichengb   

  1. a Shanghai Engineering Research Center of Tooth Restoration and Regeneration, Department of Prosthodontics, School of Stomatology, Tongji University, Shanghai 200072;
    b Department of Stomatology, Shanghai Xuhui District Dental Center, Shanghai 200032
  • Received:2015-09-25 Revised:2015-10-09 Published:2015-10-13
  • Supported by:

    Project supported by the National Natural Science Foundation of China (Nos. 81371949 and 81572114) and the Shanghai Scientific Technological Innovation Project (No. 13411951200).

The end of linear m-PEG-OH was functionalized to provide m-PEG-CTA macro-RAFT agent. RAFT homopolymerization of tBHBMA was conducted to give PEG-b-PtBHBMA diblock copolymer, which initiated ROP of lactide directly. The obtained graft copolymer, PEG-b-(PtBA-g-PLA), was then esterified with 7-methoxycoumarin-3- carboxylic acid to afford PEG-b-(PtBA-g-PLA-COU) containing fluorescent dye molecule. PEG-b-(PAA-g-PLA-COU) amphiphilic graft copolymer was prepared by selective hydrolysis of PtBA segment. Finally, doxorubicin (DOX) was loaded into polymeric micelles aggregated by PEG-b-(PAA-g-PLA-COU). The drug loading content (DLC) and size of the obtained polymeric drug micelles containing fluorescent dye molecule was measured by UV-vis and DLS.

Key words: graft copolymer, polymeric drug micelles, coumarin, doxorubicin