Chin. J. Org. Chem. ›› 2016, Vol. 36 ›› Issue (5): 962-975.DOI: 10.6023/cjoc201510012 Previous Articles     Next Articles



李杨洁, 吕子奇, 刘敏, 邢国文   

  1. 北京师范大学化学学院 北京 100875
  • 收稿日期:2015-10-12 修回日期:2015-12-28 发布日期:2016-01-07
  • 通讯作者: 邢国文
  • 基金资助:


Recent Progresses on Mitochondria-Targetable Fluorescent Probes

Li Yangjie, Lü Ziqi, Liu Min, Xing Guowen   

  1. College of Chemistry, Beijing Normal University, Beijing 100875
  • Received:2015-10-12 Revised:2015-12-28 Published:2016-01-07
  • Supported by:

    Project supported by the National Natural Science Foundation of China (No. 21272027).

Over the past few years, many bifunctional fluorescent probes based on small organic molecules, which can be located on the mitochondria to detect specific reactive small molecules (RSMs), including reactive oxygen species, reducing species, metal ions, proton and small anions, have been reported to be successful in achieving visual imaging in mitochondria. For further detection and imaging of the reactive small molecules in tissue, the design and synthesis of two-photon fluorescent probes and near-infrared fluorescent probes bearing good optical properties become increasingly popular. The recently reported mitochondrial fluorescent probes are classified, summarized and reviewed. The bright prospects of these probes in the application of preliminary diagnosis and therapy of some diseases are also discussed.

Key words: mitochondria, fluorescent probes, reactive small molecules, molecular imaging