Chin. J. Org. Chem. ›› 2016, Vol. 36 ›› Issue (8): 1954-1957.DOI: 10.6023/cjoc201601033 Previous Articles     Next Articles



任少波, 张海峰, 张剑, 张巍, 刘运奎   

  1. 浙江工业大学绿色化学与技术国家重点实验室培育基地 化学工程学院 杭州 310014
  • 收稿日期:2016-01-25 修回日期:2016-03-30 发布日期:2016-04-07
  • 通讯作者: 刘运奎
  • 基金资助:

    国家自然科学基金(Nos. 21172197和21372201)及浙江工业大学“省重中之重一级学科”开放基金资助项目.

Dichlorinating Reaction of N-Chlorosuccinimide with Isonitriles for the Synthesis of N-Phenyldichloroimides

Ren Shaobo, Zhang Haifeng, Zhang Jian, Zhang Wei, Liu Yunkui   

  1. State Key Laboratory Breeding Base of Green Chemistry-Synthesis Technology, College of Chemical Engineering, Zhejiang University of Technology, Hangzhou 310014
  • Received:2016-01-25 Revised:2016-03-30 Published:2016-04-07
  • Supported by:

    Project supported by the National Natural Science Foundation of China (Nos. 21172197 and 21372201) and the Opening Foundation of Zhejiang Key Course of Chemical Engineering and Technology, Zhejiang University of Technology.

With N-chlorosuccinimide as the chlorinating source, the dichlorination of isonitriles has been achieved to afford N-phenyldichloroimide compounds under mild and convenient conditions. The optimized reaction conditions were established through systematic investigations of the effect of solvents, temperature, time, chlorinating sources and their dosages in the reaction. The reaction exhibits good compatibility of various substrates, and a variety of isonitriles with different substituted patterns can undergo the dichlorination smoothly and furnish products with high yields of up to 93%.

Key words: isonitrile, N-chlorosuccinimide, N-phenyldichloroimide, dichlorination