Chin. J. Org. Chem. ›› 2016, Vol. 36 ›› Issue (9): 2216-2219.DOI: 10.6023/cjoc201603038 Previous Articles     Next Articles



曹团武a,b, 何康a, 耿长安a, 张雪梅a, 周俊a, 陈纪军a   

  1. a 中国科学院昆明植物研究所 植物化学与西部植物资源持续利用国家重点实验室 昆明 650201;
    b 长江师范学院化学化工学院 武陵山天然药物研究与开发实验室 涪陵 408100
  • 收稿日期:2016-03-23 修回日期:2016-04-29 发布日期:2016-06-01
  • 通讯作者: 陈纪军
  • 基金资助:


Two New Linear Monoterpenoids from Swertia mussotii

Cao Tuanwua,b, He Kanga, Geng Chang'ana, Zhang Xuemeia, Zhou Juna, Chen Jijuna   

  1. a State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201;
    b Laboratory of Natural Medicine Research and Development in Wuling Mountain, School of Chemistry and Chemical Engineering, Yangtze Normal University, Fuling 408100
  • Received:2016-03-23 Revised:2016-04-29 Published:2016-06-01
  • Supported by:

    Project supported by the National Science Foundation of China for Distinguished Young Scholar (No.81025023).

Investigation on Swertia mussotii resulted in four compounds by means of various chromatographic techniques (silica gel, Sephadex LH-20, RP-LC and Pre-HPLC). Their structures were determined as (S,2E,6E)-4,8-dihydroxy-2,6-dime-thylocta-2,6-dienoic acid (1), (S,2E,6E)-8-(formyloxy)-4-hydroxy-2,6-dimethylocta-2,6-dienoic acid (2), swerimilegenins B and C (3 and 4) on the basis of extensive spectroscopic analyses including MS, IR, UV, 1D- and 2D-NMR. Among them, compounds 1 and 2 are two new linear monoterpenoids named as swerimusic acids C (1) and D (2), compounds 3 and 4 are two unusual known secoiridoid aglycones of C9-skeleton obtained for the first time from this plant. Compounds 1~4 were evaluated for their anti-Hepatitis B Virus (HBV) activities on HepG2.2.15 cells line in vitro, but these compounds showed no anti-HBV activity at the maximal tesing concentration. Herin, we only report the isolation and structure elucidation of these compounds.

Key words: Gentianaceae, Swertia mussotii, linear monoterpenoid, swermusic acids C and D