Chin. J. Org. Chem. ›› 2016, Vol. 36 ›› Issue (12): 2858-2879.DOI: 10.6023/cjoc201606029 Previous Articles     Next Articles



鲁玲玲, 许辉, 周攀, 余富朝   

  1. 昆明理工大学生命科学与技术学院 昆明 650504
  • 收稿日期:2016-04-24 修回日期:2016-06-23 发布日期:2016-08-10
  • 通讯作者: 余富朝
  • 基金资助:

    昆明理工大学学生课外学术科技创新基金(No. 2015BA106)资助项目.

Progress in Synthesis of 1,4-Dihydropyridines

Lu Lingling, Xu Hui, Zhou Pan, Yu Fuchao   

  1. Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming 650504
  • Received:2016-04-24 Revised:2016-06-23 Published:2016-08-10
  • Supported by:

    Project supported by the Student Extracurricular Academic Science and Technology Innovation Foundation of Kunming University of Science and Technology (No. 2015BA106).

1,4-Dihydropyridines (1,4-DHPs) are an important class of heterocyclic compounds, and possess a broad array of biological activities and applications. With the development of green organic synthetic chemistry, some important achievements have been made in the green synthesis of 1,4-DHPs and new synthetic methods, which made up some shortcomings of the traditional synthesis of Hantzch reaction, such as environment friendly, synthesis efficiency, single product structure and lack of reaction type. This review provides the first overview for the green synthesis of Hantzch reaction and new synthetic methods of 1,4-DHPs since 2010. A comprehensive and up-to-date introduction are given for Hantzch reaction under geen solvent, geen catalyst and geen synthetic technology, and the new reaction of synthesis of 1,4-DHPs based on new building blocks. A thorough analysis is provided concerning the feature of improvement of green synthesis of Hantzsch reaction and new synthetic method. Moreover, the substrates, conditions, selectivities and yields have been also described. Finally, a brief discussion relating to developments and potential areas of further research concerning new synthetic methods of 1,4-DHPs and green synthesis, and chiral synthesis, is presented.

Key words: 1,4-dihydropyridines, Hantzsch reaction, clean synthesis, enaminone