Chin. J. Org. Chem. ›› 2017, Vol. 37 ›› Issue (12): 3039-3059.DOI: 10.6023/cjoc201704034 Previous Articles     Next Articles



邓颖颍, 杨文, 杨新, 杨定乔   

  1. 华南师范大学化学与环境学院 教育部环境理论化学重点实验室 广州 510006
  • 收稿日期:2017-04-19 修回日期:2017-06-21 发布日期:2017-08-11
  • 通讯作者: 杨定乔
  • 基金资助:


Progress in Iridium-Catalyzed Asymmetric Allylic Substitution Reactions with Allylic Esters

Deng Yingying, Yang Wen, Yang Xin, Yang Dingqiao   

  1. Key Laboratory of Theoretical Chemistry of Environment, Ministry of Education, School of Chemistry and Environment, South China Normal University, Guangzhou 510006
  • Received:2017-04-19 Revised:2017-06-21 Published:2017-08-11
  • Contact: 10.6023/cjoc201704034
  • Supported by:

    Project supported by the National Natural Science Foundation of China (Nos. 21172081, 21372090), the Natural Science Foundation of Guangdong Province (No. S2013020013091) and the Science and Technology Plan Projects of Guangzhou City (No. 201510010054).

Iridium-catalyzed asymmetric allylic substitution reaction is one of the most important methods for the synthesis of chiral compounds. The recent research progress in iridium-catalyzed asymmetric allylic substitution reactions of allylic ester and its derivatives is reviewed with focus on the influences of the iridium catalysts, the substrate structures of allylic ester and its derivatives, the type of nucleophiles, the effects of solvents and additives on asymmetric substitution reaction. Moreover, the possible mechanisms are also discussed in this review.

Key words: iridium catalyst, allylic esters, asymmetric allylic substitution, nucleophile, recent research progress