Chin. J. Org. Chem. ›› 2017, Vol. 37 ›› Issue (10): 2711-2716.DOI: 10.6023/cjoc201705021 Previous Articles     Next Articles



李灵杰, 张敬, 唐渝, 许开天, 张渊明   

  1. 暨南大学化学与材料学院化学系 广州 510632
  • 收稿日期:2017-05-15 修回日期:2017-06-05 发布日期:2017-06-16
  • 通讯作者: 唐渝, 张渊明;
  • 基金资助:


Catalyst-Free One-Pot Synthesis of 4-Substituted Quinazolines

Li Lingjie, Zhang Jing, Tang Yu, Xu Kaitian, Zhang Yuanming   

  1. Department of Chemistry, College of Chemistry and Materials Science, Jinan University, Guangzhou 510632
  • Received:2017-05-15 Revised:2017-06-05 Published:2017-06-16
  • Contact: 10.6023/cjoc201705021;
  • Supported by:

    Project supported by the National Natural Science Foundation of China (No.21274083).

A novel and catalyst-free one-pot method for the preparation of quinazoline compounds has been reported. Of the prepared 15 quinazoline compounds, three are new compounds. Their yields are among 37%~95%. The effects of electron effect and steric hindrance on the reaction were discussed. A plausible novel mechanism concerning repeating nucleophilic addition and elimination to give quinazoline has been proposed. By this mechanism, the reaction could be applied to acid anhydride instead of N,N-dimethylformamide (DMF).

Key words: quinazoline, one-pot, catalyst-free, Grignard reagent, synthesis