Chin. J. Org. Chem. ›› 2017, Vol. 37 ›› Issue (12): 3204-3212.DOI: 10.6023/cjoc201706002 Previous Articles     Next Articles



罗大云, 胡兴梅, 资全兴, 林军, 严胜骄   

  1. 云南大学化学科学与工程学院 教育部自然资源药物化学重点实验室 昆明 650091
  • 收稿日期:2017-06-01 修回日期:2017-07-05 发布日期:2017-08-18
  • 通讯作者: 林军, 严胜骄;
  • 基金资助:


Green Synthesis of Indanone Fused Pyrrole Compounds

Luo Dayun, Hu Xingmei, Zi Quanxing, Lin Jun, Yan Shengjiao   

  1. Key Laboratory of Medicinal Chemistry for Natural Resources, Ministry of Education, School of Chemical Science and Technology, Yunnan University, Kunming 650091
  • Received:2017-06-01 Revised:2017-07-05 Published:2017-08-18
  • Contact: 10.6023/cjoc201706002;
  • Supported by:

    Project supported by the National Natural Science Foundation of China (Nos. 21362042, 21662042, U1202221, 21262042), the Natural Science Foundation of Yunnan Province (No. 2017FA003), the Talent Found in Yunnan Province (No. 2012HB001), the Donglu Scholar of Yunnan University and the Excellent Young Talents in Yunnan University.

green synthetic method was constructed for the synthesis of indanone fused pyrrolone compounds, which based on the catalyst-free reaction of N-alkyl-1-methylthio-2-nitroethenamine (1) with ninhydrin hydrate (2) in ethanol at reflux. As a result, a series of indanone fused pyrrolones have been synthesized with 91%~98% yields by this one-step reaction. This protocol possesses some advantages including readily available starting materials, simple operation and concise synthetic route and so on.

Key words: N-alkyl-1-methylthio-2-nitroethenamine, ninhydrin, indanone, pyrrole, green synthesis