Chin. J. Org. Chem. ›› 2017, Vol. 37 ›› Issue (12): 3289-3295.DOI: 10.6023/cjoc201707024 Previous Articles     Next Articles



戴红a,b, 黄美岭b, 葛书山b, 孙思宇a, 沈爱宝a, 成晓燕a, 李春建c, 石健c   

  1. a 南通大学化学化工学院 南通 226019;
    b 南通大学药学院 南通 226001;
    c 南通大学分析测试中心 南通 226019
  • 收稿日期:2017-07-21 修回日期:2017-08-21 发布日期:2017-09-08
  • 通讯作者: 沈爱宝, 石健;
  • 基金资助:


Synthesis and Biological Activities of Novel Pyrazole Oxime Esters Containing Substituted Pyrazolyl Group

Dai Honga,b, Huang Meilingb, Ge Shushanb, Sun Siyua, Shen Aibaoa, Cheng Xiaoyana, Li Chunjianc, Shi Jianc   

  1. a College of Chemistry and Chemical Engineering, Nantong University, Nantong 226019;
    b School of Pharmacy, Nantong University, Nantong 226001;
    c Analysis and Testing Center, Nantong University, Nantong 226019
  • Received:2017-07-21 Revised:2017-08-21 Published:2017-09-08
  • Contact: 10.6023/cjoc201707024;
  • Supported by:

    Project supported by the National Natural Science Foundation of China (No. 21372135), the Research Foundation of the Six People Peak of Jiangsu Province (No. 2013-SWYY-013), and the Science and Technology Project Fund of Nantong City (No. MS22015020).

In order to explore novel pyrazole derivatives with good biological activities, a series of pyrazole-containing pyrazole oxime esters were designed and synthesized according to the method of active substructure combination. Their structures were determined by 1H NMR, 13C NMR spectra and elemental analysis. The preliminary bioactivity test showed that some of the target compounds had good insecticidal activity against Aphis medicaginis at a concentration of 500 μg/mL, some title compounds displayed good insecticidal activity against Nilaparvata lugens at 500 μg/mL. In addition, some of the designed compounds exhibited certain anti-tumor activity against HepG2 cells.

Key words: pyrazol, pyrazole oxime, synthesis, bioactivity