Chin. J. Org. Chem. ›› 2018, Vol. 38 ›› Issue (1): 51-61.DOI: 10.6023/cjoc201708030 Previous Articles     Next Articles

Special Issue: 碳氢活化合辑2018-2019



黄家翩, 顾庆, 游书力   

  1. 中国科学院上海有机化学研究所 金属有机化学国家重点实验室 上海 200032
  • 收稿日期:2017-08-15 修回日期:2017-09-13 发布日期:2017-09-15
  • 通讯作者: 顾庆, 游书力;
  • 基金资助:


Synthesis of Planar Chiral Ferrocenes via Transition-Metal-Catalyzed Direct C-H Bond Functionalization

Huang Jiapian, Gu Qing, You Shuli   

  1. State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032
  • Received:2017-08-15 Revised:2017-09-13 Published:2017-09-15
  • Contact: 10.6023/cjoc201708030;
  • Supported by:

    Project supported by the National Key R&D Program of China (No. 2016YFA0202900), the National Basic Research Program of China (973 Program, No. 2015CB856600), the National Natural Science Foundation of China (Nos. 21332009, 21421091, 21572250), and the Chinese Academy Sciences (Nos. XDB20000000, QYZDY-SSW-SLH012).

Ferrocenes bearing planar chirality have been demonstrated to be highly efficient ligands or catalysts in asymmetric catalysis. In view of their atom and step economies, direct asymmetric C—H bond functionalization is the most concise and powerful method for the construction of planar chiral ferrocenes compared with traditional approaches. This review summarizes recent progress on the development of novel methods to synthesize planar chiral compounds via transition- metal (Cu-, Pd-, Ir-, Rh-, Au-, Pt-) catalyzed asymmetric C—H bond functionalization. Preparation of a variety of new planar chiral ferrocene-based catalysts and ligands by utilizing these methods and their application in catalytic asymmetric reactions are also discussed.

Key words: transition metal catalysis, asymmetric catalysis, direct C-H bond functionalization, planar chirality, ferrocene