Chin. J. Org. Chem. ›› 2018, Vol. 38 ›› Issue (1): 118-123.DOI: 10.6023/cjoc201708037 Previous Articles     Next Articles

Special Issue: 庆祝吴养洁院士九十华诞专辑



朱新举, 牛俊龙, 赵雪梅, 郝新奇, 宋毛平   

  1. 郑州大学化学与分子工程学院 郑州 450001
  • 收稿日期:2017-08-19 修回日期:2017-11-08 发布日期:2017-11-17
  • 通讯作者: 郝新奇, 宋毛平;
  • 基金资助:


Synthesis of Chiral Bis(imidazoline) Ligands with Biphenyl Backbone and Their Application in the Asymmetric Cyclopropanation Reaction

Zhu Xinju, Niu Junlong, Zhao Xuemei, Hao Xinqi, Song Maoping   

  1. College of Chemistry and Molecular Engineering, Zhengzhou University, Zhengzhou 450001
  • Received:2017-08-19 Revised:2017-11-08 Published:2017-11-17
  • Contact: 10.6023/cjoc201708037;
  • Supported by:

    Project supported by the National Natural Science Foundation of China (Nos. 21528201, 21672192) and the China Postdoctoral Science Foundation (No. 2016M602254).

A serial of biphenyl bisimidazolines containing both axial and central chirality have been synthesized for the first time. Compared with common method, Ullmann coupling methodology exhibited superior performance expecially for t-Bu substituted ligands. The obtained ligands were further applied in the Cu-catalyzed asymmetric cyclopropanation.

Key words: imidazoline, axial chirality, central chirality, asymmetric cyclopropanation