Chin. J. Org. Chem. ›› 2018, Vol. 38 ›› Issue (5): 1035-1051.DOI: 10.6023/cjoc201709037 Previous Articles     Next Articles

Special Issue: 元素有机化学合辑2018-2019 荧光探针-生物传感合辑 有机超分子化学合辑



王浩a,b,c,d, 王凯a,b,c,d, 孙捷a,b,c,d, 方桂迁a,b,c,d, 姚庆强a,b,c,d, 吴忠玉a,b,c,d   

  1. a 济南大学 山东省医学科学院医学与生命科学学院 济南 250200;
    b 山东省医学科学院药物研究所 济南 250062;
    c 国家卫生部生物技术药物重点实验室 济南 250062;
    d 山东省罕少见病重点实验室 济南 250062
  • 收稿日期:2017-09-22 修回日期:2017-12-22 发布日期:2018-01-03
  • 通讯作者: 姚庆强,;吴忠玉,;
  • 基金资助:


Research Progress of Boronic Acid in Chemsensors

Wang Haoa,b,c,d, Wang Kaia,b,c,d, Sun Jiea,b,c,d, Fang Guiqiana,b,c,d, Yao Qingqianga,b,c,d, Wu Zhongyua,b,c,d   

  1. a School of Medicine and Life Sciences University of Jinan-Shandong Academy of Medical Sciences, Jinan 250200;
    b Institute of Materia Medica, Shandong Academy of Medical Sciences, Jinan 250062;
    c Key Laboratory for Biotech-Drugs Ministry of Health, Jinan 250062;
    d Key Laboratory of Rare and Uncommon Diseases of Shandong Province, Jinan 250062
  • Received:2017-09-22 Revised:2017-12-22 Published:2018-01-03
  • Contact: 10.6023/cjoc201709037;
  • Supported by:

    Project supported by the Shandong Provincial Natural Science Foundation (No. ZR2014YL035).

The detection and fluorescent identification of some substances such as sLea/x in vivo can provide important reference for the diagnosis, treatment and prognosis of disease, molecular tracing and further research on the mechanism of related diseases. Therefore, the development and discovery of high selectivity and high sensitivity chemsensors is of great value. Due to the special structure, phenyl boronic acid compounds could interact and bind with sugar, catecholamine containing catechol structure, fluoride or alkali cyanide. So boronic acids could be develeped as fluorescence sensors selectively for related substances, while have the advantages of high selectivity, high efficiency, rapid analysis and so on. In recent years, boronic acid has been functioned with new materials such as nanoparticles and quantum dots to design novel sensors for better performance. In this paper, the recent progress in the study of boronic acid compounds in sensors is reviewed.

Key words: boronic acid, chemsensor, fluorescence, carbohydrate, electrochemistry