Chin. J. Org. Chem. ›› 2018, Vol. 38 ›› Issue (5): 1155-1164.DOI: 10.6023/cjoc201709049 Previous Articles     Next Articles



王晶晶, 李峰, 徐妍, 王娟, 武紫燕, 杨成玉, 刘澜涛   

  1. 商丘师范学院化学化工学院 药物绿色合成河南省工程实验室 商丘 476000
  • 收稿日期:2017-09-29 修回日期:2017-12-29 发布日期:2018-01-26
  • 通讯作者: 王晶晶,;刘澜涛,;
  • 基金资助:


Catalytic Nucleophilic Addition of 3, 5-Dialkyl-4-nitroisoxazoles to Trifluoromethyl Ketones on Water

Wang Jingjing, Li Feng, Xu Yan, Wang Juan, Wu Ziyan, Yang Chengyu, Liu Lantao   

  1. Henan Engineering Laboratory of Green Synthesis for Pharmaceuticals, School of Chemistry and Chemical Engineering, Shangqiu Normal University, Shangqiu 476000
  • Received:2017-09-29 Revised:2017-12-29 Published:2018-01-26
  • Contact: 10.6023/cjoc201709049;
  • Supported by:

    Project supported by the National Natural Sciences Foundation of China (Nos. 21402116, 21502111, 21572126), the Key Scientific and Technological Project of Henan Province (No. 172102210099) and the Key Science Research of Education Committee in Henan Province (No. 15A150072).

The triethylamine catalyzed nucleophilic addition of 3, 5-dialkyl-4-nitroisoxazoles to trifluoromethyl ketones on water has been realized affording trifluoromethyl tertiary alcohol derivatives in 66%~99% yields. The products were easily transformed to the resulting alkenes by dehydration or acids by oxidation.

Key words: on water, nucleophilic addition, 3, 5-dialkyl-4-nitroisoxazoles, trifluoromethyl ketones References