Chin. J. Org. Chem. ›› 2018, Vol. 38 ›› Issue (6): 1275-1291.DOI: 10.6023/cjoc201712029 Previous Articles     Next Articles

Reviews

重氮化合物参与的连续流动反应

郜云鹏a, 王剑波a,b   

  1. a 北京大学化学与分子工程学院 生物有机与分子工程教育部重点实验室 北京分子科学国家实验室 北京 100871;
    b 中国科学院上海有机化学研究所 金属有机化学国家重点实验室 上海 200032
  • 收稿日期:2017-12-20 修回日期:2018-01-22 出版日期:2018-06-25 发布日期:2018-02-06
  • 通讯作者: 王剑波,E-mail:wangjb@pku.edu.cn E-mail:wangjb@pku.edu.cn
  • 基金资助:

    国家自然科学基金(No.21332002)和国家重点基础研究发展计划(973计划,No.2015CB856600)资助项目.

Continuous Flow Reaction of Diazo Compounds

Gao Yunpenga, Wang Jianboa,b   

  1. a Beijing National Laboratory of Molecular Sciences(BNLMS) and Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry, Peking University, Beijing 100871;
    b State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032
  • Received:2017-12-20 Revised:2018-01-22 Online:2018-06-25 Published:2018-02-06
  • Contact: 10.6023/cjoc201712029 E-mail:wangjb@pku.edu.cn
  • Supported by:

    Project supported by the National Natural Science Foundation of China (No. 21332002) and the National Basic Research Program of China (973 Program, No. 2015CB856600).

Diazo compounds are versatile building blocks in organic synthesis. They are served as 1,3-dipoles, nucleophiles and carbene precursors in the construction of various organic molecules. However, the utility of diazo compounds is significantly limited by toxicity, instability and explosive potential. The application of continuous flow technology in this field could ensure the safety of these reactions. It also provides the possibility to utilize diazo compounds in a large scale. Categorized by the types of diazo compounds, the application of continuous flow technology in transformations of diazo compounds is systematically reviewed in this paper.

Key words: diazo compound, flow chemistry, microreactor, organic synthesis