Chin. J. Org. Chem. ›› 2018, Vol. 38 ›› Issue (6): 1431-1436.DOI: 10.6023/cjoc201801034 Previous Articles     Next Articles



李哲健a, 高宝b, 黄汉民b   

  1. a 浙江工业大学化学工程学院 杭州 310014;
    b 中国科学技术大学化学系 合肥微尺度物质科学国家研究中心 合肥 230026
  • 收稿日期:2018-01-24 修回日期:2018-03-06 发布日期:2018-03-08
  • 通讯作者: 黄汉民,
  • 基金资助:


Amidation of Acid Chlorides to Primary Amides with Ammonium Salts

Li Zhejiana, Gao Baob, Huang Hanminb   

  1. a College of Chemical Engineering, Zhejiang University of Technology, Hangzhou 310014;
    b Hefei National Laboratory for Physical Sciences at the Microscale, Department of Chemistry, University of Science and Technology of China, Hefei 230026
  • Received:2018-01-24 Revised:2018-03-06 Published:2018-03-08
  • Contact: 10.6023/cjoc201801034
  • Supported by:

    Project supported by the National Natural Science Foundation of China (Nos. 21672199, 21702197), the CAS Interdisciplinary Innovation Team, the Fundamental Research Funds for the Central Universities and the Anhui Provincial Natural Science Foundation (No. 1708085MB28).

A practical amidation reaction for the synthesis of primary amides is presented, in which the simple NH4Cl was identified as a practical and convenient amine source. A series of aromatic and aliphatic acid chlorides were successfully compatible with this protocol, affording the corresponding amides in good to excellent yields, which provides a rapid and reliable approach to amides from simple starting materials. Introducing the appropriate N-methyl pyrrolidone (NMP) into the system as solvent and acid-binding reagent plays a key role to avoid the use of stoichiometric amounts of base.

Key words: ammonium salts, amidation, primary amides, acid chlorides, N-methyl pyrrolidone