Chin. J. Org. Chem. ›› 2018, Vol. 38 ›› Issue (9): 2412-2419.DOI: 10.6023/cjoc201804014 Previous Articles     Next Articles

Special Issue: 合成科学

Reviews

镜像手性蛋白质研究进展

黎子琛, 张宝昌, 左冲, 刘磊   

  1. 清华大学化学系 生命有机磷化学及化学生物学教育部重点实验室 100084
  • 收稿日期:2018-04-09 修回日期:2018-05-04 出版日期:2018-09-25 发布日期:2018-05-17
  • 通讯作者: 刘磊 E-mail:lliu@mail.tsinghua.edu.cn
  • 基金资助:

    科技部国家重点研发计划(No.2017YFA0505200)和国家自然科学基金(Nos.21750005,21532004,91753205)资助项目.

Studies on Mirror-Image Proteins

Li Zichen, Zhang Baochang, Zuo Chong, Liu Lei   

  1. Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology, Ministry of Education, Department of Chemistry, Tsinghua University, Beijing 100084
  • Received:2018-04-09 Revised:2018-05-04 Online:2018-09-25 Published:2018-05-17
  • Contact: 10.6023/cjoc201804014 E-mail:lliu@mail.tsinghua.edu.cn
  • Supported by:

    Project supported by the National Key R&D Program of China (No. 2017YFA0505200) and the National Natural Science Foundation of China (Nos. 21750005, 21532004, 91753205).

Mirror-image proteins are composed of D-amino acids and glycine. They are the enantiomers of the native L-protein counterparts. Currently mirror-image proteins can not be obtained through recombinant technology and therefore, chemical synthesis is the only way to generate mirror-image proteins. As structurally defined and functionally variable chemical materials, mirror-image proteins have potential applications in racemic crystallography, biomimetic catalysis, soft materials, and diagnostics and therapeutic reagents. The chemical synthesis of mirror-image proteins and the advances in racemic X-ray crystallography, mirror-image drug discovery, as well as mirror-image biological systems are surveyed.

Key words: mirror-image protein, protein chemical synthesis, racemic crystallography, mirror-image phage display, mirror-image biosystem