Chin. J. Org. Chem. ›› 2018, Vol. 38 ›› Issue (9): 2199-2214.DOI: 10.6023/cjoc201805060 Previous Articles     Next Articles

Special Issue: 合成科学

Reviews

植物天然化合物的人工合成之路

王平平a, 杨成帅a,b, 李晓东a,b, 蒋雨果a,b, 严兴a, 周志华a   

  1. a 中国科学院分子植物科学卓越创新中心/植物生理生态研究所 中国科学院合成生物学重点实验室 上海 200032;
    b 中国科学院大学 北京 100049
  • 收稿日期:2018-05-31 修回日期:2018-07-30 出版日期:2018-09-25 发布日期:2018-08-23
  • 通讯作者: 周志华 E-mail:zhouzhihua@sippe.ac.cn
  • 基金资助:

    国家自然科学基金(No.21672228)、中国科学院重点部署项目(Nos.KFZD-SW-215)、中国科学院B类先导科技专项培育项目(No.XDPB0400)和中国科学院国际大科学计划(No.153D31KYSB20170121)资助项目.

Route to Artificially Synthesize Plant Natural Products

Wang Pingpinga, Yang Chengshuaia,b, Li Xiaodonga,b, Jiang Yuguoa,b, Yan Xinga, Zhou Zhihuaa   

  1. a CAS-Key Laboratory of Synthetic Biology, CAS Center for Excellence in Molecular Plant Sciences, Shanghai Institute of Plant Physiology and Ecology, Chinese Academy of Sciences, Shanghai 200032;
    b University of Chinese Academy of Sciences, Beijing 100049
  • Received:2018-05-31 Revised:2018-07-30 Online:2018-09-25 Published:2018-08-23
  • Contact: 10.6023/cjoc201805060 E-mail:zhouzhihua@sippe.ac.cn
  • Supported by:

    Project supported by the National Natural Science Foundation of China (No. 21672228), the Key Deployment Projects of the Chinese Academy of Sciences (Nos. KFZD-SW-215), the "Strategic Priority Research Program" of the Chinese Academy of Sciences (No. XDPB0400) and the International Great Science Program of the Chinese Academy of Sciences (No. 153D31KYSB20170121).

Plant natural products and their derivatives are the important reservoirs for the development of medicines, health products and food additives. The synthetic biology technology brings new strategies to manufacture rare plant natural products with complicated structures at large scale by artificially constructing and optimizing the biosynthesis pathway of target compounds in microbial chassis cells. In this paper, the research progress on the artificial syntheses of important plant natural products such as artemisinin, ginsenosides, morphinan alkaloids, paclitaxel and vinblastine is reviewed. These examples not only demonstrate the great potentials of synthetic biology as well as its combination with synthetic chemistry applied in the artificial syntheses of plant natural compounds, but also show us the roadmap for future research and development on de novo synthesis of plant natural products. New technologies developed in synthetic biology and synthetic chemistry would further promote the unveiling of biosynthetic pathways of complex natural compounds, the discovery and characterization of key bioparts, the design and building of novel chassis cells, the strong-strong combination of biosynthesis and chemical synthesis, and thus accelerate the process to transfer the developed technologies to artificially synthesize plant natural products from laboratories to markets.

Key words: synthetic biology, synthetic chemistry, de novo synthesis, biosynthetic pathway, biopart, chassis cell, genomic editing