Chin. J. Org. Chem. ›› 2018, Vol. 38 ›› Issue (12): 3363-3372.DOI: 10.6023/cjoc201807001 Previous Articles     Next Articles



张凯a, 李加荣a, 温都苏a, 刘洪林b, 王海邮b, 阿拉木斯b   

  1. a 北京理工大学化学与化工学院 北京 100081;
    b 中国农业科学院草原研究所 呼和浩特 010000
  • 收稿日期:2018-07-01 修回日期:2018-08-02 发布日期:2018-09-05
  • 通讯作者: 李加荣
  • 基金资助:


Study on the Synthesis and Insecticidal Activity of Spinosyn A Derivatives

Zhang Kaia, Li Jiaronga, Wen Dusua, Liu Honglinb, Wang Haiyoub, A Lamusib   

  1. a School of Chemistry and Chemical Engineering, Beijing Institute of Technology, Beijing 100081;
    b Institute of Grassland Research of Chinese Academy of Agricultural Sciences, Hohhot 010000
  • Received:2018-07-01 Revised:2018-08-02 Published:2018-09-05
  • Contact: 10.6023/cjoc201807001
  • Supported by:

    Project supported by the National Natural Science Foundation of China (No. 41471198).

Spinosyns are a novel kind of biopesticide produced by Saccharopolyspora spinosa. Spinosyns have been widely applied in pest control because of their broad insecticidal spectrum, high insecticidal activity, low environmental impact, and low toxicity. To identify spinosyn compounds with improved insecticidal activity, a series of D-forosamine replacement derivatives of spinosyn A were synthesized. The insecticidal activities of the synthetic derivatives were evaluated against 3rd-instar larvae of Plutella xylostella. All derivatives exhibited good insecticidal activity to P. xylostella.

Key words: natural product, spinosyn A, semi-synthetic derivative, insecticidal activity