Chin. J. Org. Chem. ›› 2019, Vol. 39 ›› Issue (3): 668-678.DOI: 10.6023/cjoc201807038 Previous Articles     Next Articles



廖旭a, 蒋岩b, 赖石林a, 刘源岗b, 王士斌b, 熊兴泉a   

  1. a 华侨大学材料科学与工程学院 厦门 361021;
    b 华侨大学化工学院 厦门 361021
  • 收稿日期:2018-07-23 修回日期:2018-09-25 发布日期:2018-10-26
  • 通讯作者: 熊兴泉
  • 基金资助:


Chemoenzymatic Relay Reaction and Its Applications in Highly Efficient and Green Synthesis of High-Value Chiral Compounds

Liao Xua, Jiang Yanb, Lai Shilina, Liu Yuangangb, Wang Shibinb, Xiong Xingquana   

  1. a College of Materials Science and Engineering, Huaqiao University, Xiamen 361021;
    b College of Chemical Engineering, Huaqiao University, Xiamen 361021
  • Received:2018-07-23 Revised:2018-09-25 Published:2018-10-26
  • Contact: 10.6023/cjoc201807038
  • Supported by:

    Project supported by the National Natural Science Foundation of China (No. 21004024), the Natural Science Foundation of Fujian Province (No. 2016J01063), the Program for New Century Excellent Talents in Fujian Province (No. 2012FJ-NCET-ZR03), the University Distinguished Young Research Talent Training Program of Fujian Province (No. 11FJPY02) and the Subsidized Project for Postgraduates' Innovative Fund in Scientific Research of Huaqiao University (No. ZQN-YX103).

Compared with traditional chemical catalysis or enzymatic synthesis, chemoenzymatic relay reaction is a simpler, more efficient and economical method. It not only has the advantages of high efficiency and selectivity of enzyme catalysis, but also has the advantages of low price of synthetic raw materials, simple and high efficiency of synthetic process, green and friendly production environment, and excellent optical purity of the obtained product. Thus, chemoenzymatic relay synthesis methods have been widely used in the synthesis of high-value chiral compounds. In recent years, chemists have been committed to making chemoenzymatic catalytic conditions easier by changing catalysts and designing more reasonable ways, which could be used in more fields. In this review, the recent progress in the synthesis of chiral alcohols, epoxides, heterocyclics and other chiral compounds by using chemoenzymatic relay synthesis, such as enzyme and metal catalysis, enzyme and organic catalysis, enzyme and new reaction techniques, is reviewed, and the development trends of this field are also prospected.

Key words: chemoenzymatic, relay reaction, high-value chiral compound, enzyme-metal catalysis, enzyme-organic catalysis