Chin. J. Org. Chem. ›› 2019, Vol. 39 ›› Issue (7): 1875-1890.DOI: 10.6023/cjoc201811002 Previous Articles     Next Articles



徐焕基a, 李哲明a, 吴云秋a, 罗迪a, 邱莉a, 谢集照a,b, 李雪华a   

  1. a 广西医科大学药学院 南宁 530021;
    b 广西大学化学化工学院 南宁 530004
  • 收稿日期:2018-11-01 修回日期:2019-01-23 发布日期:2019-02-19
  • 通讯作者: 谢集照, 李雪华;
  • 基金资助:


Advances on Synthesis of Flavonoid Glycosides

Xu Huanjia, Li Zheminga, Wu Yunqiua, Luo Dia, Qiu Lia, Xie Jizhaoa,b, Li Xuehuaa   

  1. a School of Pharmacy, Guangxi Medical University, Nanning 530021;
    b School of Chemistry and Chemical Engineering, Guangxi University, Nanning 530004
  • Received:2018-11-01 Revised:2019-01-23 Published:2019-02-19
  • Contact: 10.6023/cjoc201811002;
  • Supported by:

    Project supported by the National Natural Science Foundation of China (No. 21662005).

Flavonoid glycoside is commonly found in natural plants, possesses diverse bioactivities and potential medicinal values, and its synthesis methods are worthy to be studied. The synthesis of flavonoid glycosides covering the literatures from 2014 to 2018 is reviewed. The flavonoid glycoside synthesis includes two major methods of chemosynthesis and biosynthesis. Chemosynthesis includes total synthesis and semi-synthesis. The total synthesis has two classical methods of the Baker- Venkataraman (BK-VK) reaction and the Algar-Flynn-Oyamada (AFO) reaction. The semi-synthesis is usually starting from natural flavonoid, such as rutin, quercetin, kaempferol, naringenin and so on. Moreover, the chemosynthesis of flavonoid O-glucoside has three prime methods, Koening-Knorr method, phase transfer catalysis method, and glycosyl trichloroacetimidate method. As for the chemosynthesis of flavonoid C-glycoside, its glycosidic linkage is mainly completed via the O→C rearrangement reaction. Currently, the glycosyltransferase and glycosynthase are usually employed in the enzyme-catalyzed biosynthesis of flavonoid glycosides.

Key words: flavonoid glycosides, synthesis, flavonoid aglycones, condensation of glycosides, review