Chinese Journal of Organic Chemistry ›› 2019, Vol. 39 ›› Issue (11): 3244-3249.DOI: 10.6023/cjoc201903024 Previous Articles     Next Articles


AhmadMuhammad Siddique, 主亚敏, 郭云龙, 张赛赛, 沈增明*()   

  1. 上海交通大学化学化工学院 上海 200240
  • 收稿日期:2019-03-14 发布日期:2019-06-12
  • 通讯作者: 沈增明
  • 基金资助:

Copper-Catalyzed Aerobic Oxidation Strategy: A Concise Route to Isatin

Ahmad Muhammad Siddique, Zhu Yamin, Guo Yunlong, Zhang Saisai, Shen Zengming*()   

  1. School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai 200240
  • Received:2019-03-14 Published:2019-06-12
  • Contact: Shen Zengming
  • Supported by:
    the National Natural Sciences Foundation of China(21672144)

A copper-catalyzed decarbonylation cyclization to form isatins using oxygen as terminal oxidant is developed. This complementary way offers a new protocol for the synthesis of isatins through C(sp3)—H bond functionalization in Cu/O2/Co system. This system shows good reactivity and compatibility. Both electron-rich and electron-deficient functional groups can be tolerated. A postulated mechanism is proposed based on mechanistic studies and previous reports.

Key words: Cu catalyst, C—H bond activation, isatin, decarbonylation, oxygen