Chinese Journal of Organic Chemistry ›› 2019, Vol. 39 ›› Issue (10): 2735-2743.DOI: 10.6023/cjoc201904011 Previous Articles     Next Articles

Special Issue: 碳氢活化合辑2018-2019



唐灏a, 骆钧飞a*(), 解攀b*()   

  1. a 宁波大学材料科学与化学工程学院 宁波 315211
    b 陕西科技大学化学与化工学院 陕西省轻化工助剂重点实验室 西安 710021
  • 收稿日期:2019-04-04 修回日期:2019-05-09 发布日期:2019-06-06
  • 通讯作者: 骆钧飞,解攀;
  • 基金资助:

Advances on the Synthesis of Aryl Ethers via Dehydrogenative Coupling

Tang Haoa, Luo Junfeia*(), Xie Panb*()   

  1. a School of Materials Science and Chemical Engineering, Ningbo University, Ningbo 315211
    b Shaanxi Key Laboratory of Chemistry Additives for Industry, College of Chemistry and Chemistry Engineering, Shaanxi University of Science & Technology, Xi?an 710021
  • Received:2019-04-04 Revised:2019-05-09 Published:2019-06-06
  • Contact: Luo Junfei,Xie Pan;
  • Supported by:
    Project supported by the Natural Science Foundation of Zhejiang Province(LQ19B020002);The Municipal Natural Science Foundation of Ningbo City(2018A610241);The Education Foundation of Zhejiang Province(Y201839228);The K. C. Wong Magna Fund in Ningbo University

Aryl ethers are important central motifs that are abundant in many natural products and drug molecules, as well as versatile building blocks for organic synthesis. Aryl ethers were usually synthesized through the coupling reactions between leaving group substituted arenes and alcohols. However, the introduction of leaving group requires extra synthetic operation and produces lots of wastes. Over the past decade, the method for the synthesis of aryl ethers via C—H alkoxylation or aryloxylation has received much attention due to its potential as an atom and step efficient methodology. Herein, the research advances on the synthesis of aryl ethers through dehydrogenative coupling are reviewed. The detailed substrate scopes and reaction mechanisms, as well as the limitations of current procedures and the prospects for the future, are discussed.

Key words: aryl ether, dehydrogenative coupling, C—H activation, phenol, alcohol