Chinese Journal of Organic Chemistry ›› 2019, Vol. 39 ›› Issue (10): 2744-2758.DOI: 10.6023/cjoc201904023 Previous Articles     Next Articles

REVIEW

吩嗪-1-羧酸及其类似物研究进展

朱祥a, 吴清来ab*(), 李俊凯ab*()   

  1. a 长江大学农学院 荆州 434025
    b 长江大学农药研究所 荆州 434025
  • 收稿日期:2019-04-09 修回日期:2019-05-16 出版日期:2019-10-25 发布日期:2019-06-03
  • 通讯作者: 吴清来,李俊凯 E-mail:wql106@163.com;junkaili@sina.com.com
  • 基金资助:
    国家重点研发计划(2018YFD0200500);国家自然科学基金(31672069);长江大学优秀博士学位论文培育计划资助项目

Research Progress of Phenazine-1-carboxylic Acid and Its Analogue

Zhu Xianga, Wu Qinglaiab*(), Li Junkaiab*()   

  1. a School of Agriculture, Yangtze University, Jingzhou 434025
    b Institute of Pesticides, Yangtze University, Jingzhou 434025
  • Received:2019-04-09 Revised:2019-05-16 Online:2019-10-25 Published:2019-06-03
  • Contact: Wu Qinglai,Li Junkai E-mail:wql106@163.com;junkaili@sina.com.com
  • Supported by:
    Project supported by the National Key R&D Program of China(2018YFD0200500);The National Natural Science Foundation of China(31672069);The Funds for Excellent Doctoral Dissertation Cultivation Program in Yangtze University

Phenazine-1-carboxylic acid (PCA) as a natural product widely exists in microbial metabolites of Pseudomonads and Streptomycetes, which displays potent inhibitory activities against plant pathogens, and has medical antibacterial and antitumor effects, and so on. In this review, the biosynthesis and chemosynthesis of phenazine-1-carboxylic acid are summarized. At the same time, the diverse biological evaluations of its biosynthetic and chemosynthetic analogues are summarized, which could provide reference for the study of structural modifications and biological activities of these analogues.

Key words: phenazine-1-carboxylic acid, analogues, research progress