Chinese Journal of Organic Chemistry ›› 2019, Vol. 39 ›› Issue (10): 2759-2770.DOI: 10.6023/cjoc201904055 Previous Articles     Next Articles


四降三萜solanoeclepin A的合成研究进展

孙茂a, 邱发洋d*(), 李卫东bc*()   

  1. a 安顺市人民医院 药学实验室 安顺 561000
    b 重庆大学药学院 天然产物全合成与创新药物研究重庆市重点实验室 重庆 401331
    c 西南交通大学生命科学与工程学院 成都 610031
    d 中国科学院广州生物医药与健康研究院 广州 510530
  • 收稿日期:2019-04-23 修回日期:2019-05-13 发布日期:2019-06-03
  • 通讯作者: 邱发洋,李卫东;
  • 基金资助:

Recent Progresses in the Synthesis of Solanoeclepin A

Sun Maoa, Qiu Fayangd*(), Li Wei-Dongbc*()   

  1. a Pharmaceutical Laboratory, An Shun City People’s Hospital, Anshun 561000;
    b Chongqing Key Laboratory of Natural Product Synthesis and Drug Research, School of Pharmaceutical Sciences, Chongqing University, Chongqing 40133
    c School of Life Science and Engineering, Southwest Jiaotong University, Chengdu 610031
    d Guangzhou Institute of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530
  • Received:2019-04-23 Revised:2019-05-13 Published:2019-06-03
  • Contact: Qiu Fayang,Li Wei-Dong;
  • Supported by:
    Project supported by the National Natural Science Foundation of China(21672030)

Solanoeclepin A, first isolated from potato roots (Solanaceae Juss.) by Mulder et al., is an highly active hatching stimulant (0.3 g per hectare) of potato cyst nematode (PCN, Globodera rostochiensis and G. pallida) which causes severe damage to potato crops. Its complex chemical structure belongs to a rearranged tetranortriterpene and possesses extremely unique skeleton. Based on the known general biosynthesis of tetranortriterpenoids and Prof. Corey’s biomimetic synthesis of glycinoeclepin, a plausible biosynthetic pathway of solanoeclepin A is proposed. A schematic review on the synthetic studies towards solanoeclepin A is provided.

Key words: solanoeclepin A, tetranortriterpene, natural product, total synthesis