Chinese Journal of Organic Chemistry ›› 2020, Vol. 40 ›› Issue (1): 156-161.DOI: 10.6023/cjoc201905040 Previous Articles     Next Articles

深共融溶剂中合成2,4-二取代喹啉衍生物

陈国庆a,b, 谢宗波a,b, 刘一帅b, 孟佳b, 乐长高a,b   

  1. a 东华理工大学核资源与环境国家重点实验室 南昌 330013;
    b 东华理工大学应用化学系 南昌 330013
  • 收稿日期:2019-05-19 修回日期:2019-07-20 出版日期:2020-01-25 发布日期:2019-09-05
  • 通讯作者: 谢宗波, 乐长高 E-mail:zbxie@ecut.edu.cn;zhgle@ecut.edu.cn
  • 基金资助:
    国家自然科学基金(Nos.21462001,11765002)、江西省科技计划(Nos.20161BCB24006,20181BAB203019)资助项目.

Synthesis of 2,4-Disubstituted Quinolines in Deep Eutectic Solvents

Chen Guoqinga,b, Xie Zongboa,b, Liu Yishuaib, Meng Jiab, Le Zhanggaoa,b   

  1. a State Key Laboratory of Nuclear Resources and Environment, East China University of Technology, Nanchang 330013;
    b Department of Applied Chemistry, East China University of Technology, Nanchang 330013
  • Received:2019-05-19 Revised:2019-07-20 Online:2020-01-25 Published:2019-09-05
  • Supported by:
    Project supported by the National Natural Science Foundation of China (Nos. 21462001, 11765002), and the Science and Technology Projects of Jiangxi Province (Nos. 20161BCB24006, 20181BAB203019).

In the deep eutectic solvent which composed of choline chloride and zinc chloride, a series of 2,4-disubstituted quinolines were synthesized via cyclization coupling of 2-aminoacetophenone and aromatic alkyne. When the molar ratio of choline chloride and zinc chloride was 1:2, the yield up to 98% was achieved at 80℃ for 3 h. The method does not need additional catalyst, and has the advantages of mild reaction conditions, simple operation and a wide range of substrates.

Key words: deep eutectic solvent, choline chloride, zinc chloride, cyclization coupling, 2,4-disubstituted quinoline