Chinese Journal of Organic Chemistry ›› 2020, Vol. 40 ›› Issue (3): 756-762.DOI: 10.6023/cjoc201907030 Previous Articles     Next Articles


史望宇, 徐嘉擎, 毛比明, 贾皓, 黄家兴, 郭红超   

  1. 中国农业大学理学院化学系 北京 100193
  • 收稿日期:2019-07-22 修回日期:2019-10-18 发布日期:2019-11-01
  • 通讯作者: 黄家兴, 郭红超;
  • 基金资助:

[3+2] Cycloaddition of Methylenedihydrobenzofurandiones and Nitrilimines: Synthesis of Sipropyrazole Compounds

Shi Wangyu, Xu Jiaqing, Mao Biming, Jia Hao, Huang Jiaxing, Guo Hongchao   

  1. Department of Chemistry, College of Science, China Agricultural University, Beijing 100193
  • Received:2019-07-22 Revised:2019-10-18 Published:2019-11-01
  • Supported by:
    Project supported by the National Natural Science Foundation of China (No. 21572264).

The[3+2] cycloaddition of methylenedihydrobenzofurandiones and nitrilimines worked efficiently in CHCl3 at room temperature in the presence of Et3N, producing biologically interesting spirocyclic pyrazole derivatives in high yield (78%~94%) with excellent diastereoselectivity.

Key words: cycloaddition, nitrilimine, spirocyclic compound, pyrazole