Chinese Journal of Organic Chemistry ›› 2019, Vol. 39 ›› Issue (11): 3026-3039.DOI: 10.6023/cjoc201907051 Previous Articles     Next Articles

配体促进的水介质/纯水中铜催化C-N交叉偶联反应研究进展

谢建伟ab*(), 汪小创b, 吴丰田c, 张洁b   

  1. a 湖南科技学院化学与生物工程学院 湖南永州 425199
    b 石河子大学化学化工学院 新疆兵团化工绿色过程重点实验室-省部共建国家重点实验室培育基地 新疆石河子 832003
    c 东华理工大学 江西省聚合物微纳制造与器件重点实验室 南昌 330013
  • 收稿日期:2019-07-29 出版日期:2019-11-25 发布日期:2019-10-09
  • 通讯作者: 谢建伟 E-mail:cesxjw@foxmail.com
  • 基金资助:
    国家自然科学基金(21606153);国家自然科学基金(21868032)

Research Progress in Ligand-Assisted Copper-Catalyzed C-N Cross-Coupling Reaction in Aqueous Media or Pure Water

Xie Jianweiab*(), Wang Xiaochuangb, Wu Fengtianc, Zhang Jieb   

  1. a College of Chemistry and Bioengineering, Hunan University of Science and Engineering, Yongzhou, Hunan 425199
    b Key Laboratory for Green Processing of Chemical Engineering of Xinjiang Bingtuan, School of Chemistry and Chemical Engineering, Shihezi University, Shihezi, Xinjiang 832003
    c Jiangxi Province Key Laboratory of Polymer Micro/Nano Manufacturing and Devices, East China University of Technology, Nanchang 330013
  • Received:2019-07-29 Online:2019-11-25 Published:2019-10-09
  • Contact: Xie Jianwei E-mail:cesxjw@foxmail.com
  • Supported by:
    the National Natural Science Foundation of China(21606153);the National Natural Science Foundation of China(21868032)

Copper-catalyzed Ullmann-type C-N coupling reaction is one of the most effective methods to construct the C-N bonds. Water, as green and clean solvent, has been successfully employed in various organic reactions. According to the structure of ligands, the progress of ligand-assisted copper-catalyzed C-N cross-coupling reaction in aqueous media or pure water is summarized comprehensively, and the ligands include diamines, hydrazides, phenanthrolines, carbohydrates, pyridine-N-oxides, quinolines, oximes and salen. In addition, ligand-free copper-catalyzed C-N coupling reactions in aquous media or pure water are also reviewed.

Key words: ligand-assisted, copper catalyst, aqueous media/pure water, C-N cross-coupling