Chinese Journal of Organic Chemistry ›› 2020, Vol. 40 ›› Issue (4): 930-937.DOI: 10.6023/cjoc201910014 Previous Articles     Next Articles


鲍堃a,b, 危俊b, 盛荣b   

  1. a 浙江工业大学 长三角绿色制药协同创新中心 杭州 310014;
    b 浙江大学药学院 杭州 310058
  • 收稿日期:2019-10-11 修回日期:2019-12-07 发布日期:2019-12-27
  • 通讯作者: 盛荣

Synthesis of α,α,γ,γ-Tetrafluoro-β-hydroxy Ketones and α-Fluoroacetophenones via 1,3-Diaryl-1,3-diketones

Bao Kuna,b, Wei Junb, Sheng Rongb   

  1. a Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou 310014;
    b College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058
  • Received:2019-10-11 Revised:2019-12-07 Published:2019-12-27

α,α,γ,γ-Tetrafluoro-β-hydroxy ketones and α-fluoroacetophenones are widely used in the fields of organic chemistry, agrochemicals, and pharmaceuticals. A mild and excellent method to synthesize α,α,γ,γ-tetrafluoro-β-hydroxy ketones and α-fluoroacetophenones via various 1,3-diaryl-1,3-diketones has been developed. With the modification of reaction conditions, two different products could be obtained in moderate to good yields, respectively.

Key words: α,α,γ,γ-tetrafluoro-β-hydroxy ketones, α-fluoroacetophenones, 1,3-diaryl-1,3-diketones